Two codependent routes lead to high-level MRSA

Methicillin-resistant Staphylococcus aureus (MRSA) exhibits resistance to β-lactam antibiotics due to the acquisition of penicillin-binding protein 2a (PBP2a). In antibiotic-administered conditions, MRSA adopts an alternative cell division mode and alters the peptidoglycan architecture at the division septum. This resensitizing agent interferes with these mechanisms, offering new interventions.